Articles

Savelev Sergei¹, Belova Tatyana², Nikitina Valeria³, Pavlova Natalia⁴, Frolova Yulia⁵, Sharipov Danil⁶ ABSTRACT: Background: Placental insufficiency is a pathological condition characterized by inadequate perfusion and functional impairment of the placenta, resulting in suboptimal nutrient and oxygen delivery to the fetus. This condition is a major contributor to a spectrum of obstetric complications, including intrauterine growth […]

Ivanova Polina¹, Matsumoto Daichi², Riaz Zara³, Carvalho Tiago⁴, Krämer Niklas⁵, Dubois Inès⁶ ABSTRACT: Background: Precision medicine seeks to tailor diagnostics and therapeutics to individual molecular profiles, and translational biochemistry plays a pivotal role in bridging benchside discoveries with clinical application. By elucidating the biochemical underpinnings of disease heterogeneity, translational approaches enable the identification of actionable

Smirnov Oleg¹, Tanaka Yuto², Zubair Fariha³, Almeida Sérgio⁴, Fuchs Tobias⁵, Morel Amandine⁶ ABSTRACT: Background: The functional state of immune cells is intricately linked to their metabolic programs, which dynamically adjust in response to environmental cues and immunological demands. The interface between biochemistry and immunology—often termed immunometabolism—has revealed that metabolic pathways are not merely passive providers

Volkova Yulia¹, Nakamura Sho², Hassan Amara³, Nogueira Paulo⁴, Weber Simon⁵, Bernard Lucie⁶ ABSTRACT: Background: Climate change imposes multifaceted biochemical stressors on plants, including elevated temperatures, increased atmospheric CO₂, and altered precipitation patterns. These environmental shifts disrupt the finely tuned enzymatic and metabolic networks that underlie plant growth, development, and adaptation. Understanding how climate-induced stress affects

Klimova Ekaterina¹, Takahashi Sora², Jamil Farah³, Ribeiro Vasco⁴, Braun Matthias⁵, Chevallier Maëlle⁶ ABSTRACT: Background: Synthetic biochemistry offers a transformative platform for reconstituting and engineering complex metabolic pathways outside of living cells. By assembling purified enzymes in cell-free systems, this approach decouples metabolic design from cellular growth constraints, enabling unprecedented control over flux distribution, cofactor recycling,

Pavlov Dmitry¹, Yamamoto Kei², Naqvi Huda³, Ferreira Miguel⁴, Schneider Erik⁵, Lemoine Émilie⁶ ABSTRACT: Background: Cellular aging is a complex, multifactorial process that results from the cumulative interplay between metabolic dysfunction, epigenetic remodeling, and oxidative stress. These interconnected biochemical pathways contribute to the progressive decline in cellular homeostasis, increased susceptibility to disease, and loss of regenerative

Sorokina Alisa¹, Fujii Naoki², Tariq Yasmin³, Carvalho Duarte⁴, Reinhardt Leon⁵, Dubois Victoire⁶ ABSTRACT: Background: The global escalation of antibiotic resistance poses a profound threat to public health, undermining decades of progress in infectious disease management. At the core of this crisis lie diverse and rapidly evolving biochemical mechanisms that bacteria employ to evade the action

Gromova Tatiana¹, Kobayashi Taichi², Riaz Mahnoor³, Figueiredo Rafael⁴, Schiller Jonas⁵, Laurent Élise⁶ ABSTRACT: Background: The bacterium Escherichia coli remains one of the most widely used expression systems for recombinant protein production due to its rapid growth, well-characterized genetics, and cost-effectiveness. However, despite its utility, the system is often hampered by biochemical bottlenecks that affect yield,

Gromova Tatiana¹, Kobayashi Taichi², Riaz Mahnoor³, Figueiredo Rafael⁴, Schiller Jonas⁵, Laurent Élise⁶ ABSTRACT: Background: Plant secondary metabolites constitute a vast and structurally diverse reservoir of bioactive compounds that have evolved to mediate ecological interactions such as defense, signaling, and adaptation. These molecules—including alkaloids, terpenoids, flavonoids, and phenolics—exhibit potent pharmacological activities and serve as privileged scaffolds

Nikiforov Alexey¹, Yamashita Yui², Shahbaz Noor³, Ribeiro Gonçalo⁴, Wagner Elias⁵, Girard Anaïs⁶ ABSTRACT: Background: Poor drug bioavailability remains a major obstacle in therapeutic efficacy, particularly for hydrophobic compounds, macromolecules, and agents with narrow absorption windows or rapid degradation. Nanocarrier systems—such as liposomes, polymeric nanoparticles, solid lipid nanoparticles, dendrimers, and micelles—have emerged as transformative platforms to