Placental Insufficiency: Modern Methods of Diagnosisand Prevention of Pregnancy Complications
Savelev Sergei¹, Belova Tatyana², Nikitina Valeria³, Pavlova Natalia⁴, Frolova Yulia⁵, Sharipov Danil⁶ ABSTRACT: Background: Placental insufficiency is a pathological condition characterized by inadequate perfusion and functional impairment of the placenta, resulting in suboptimal nutrient and oxygen delivery to the fetus. This condition is a major contributor to a spectrum of obstetric complications, including intrauterine growth
Translational Biochemistry in Precision Medicine: Molecular Targets, Biomarkers, and Therapeutic Strategies
Ivanova Polina¹, Matsumoto Daichi², Riaz Zara³, Carvalho Tiago⁴, Krämer Niklas⁵, Dubois Inès⁶ ABSTRACT: Background: Precision medicine seeks to tailor diagnostics and therapeutics to individual molecular profiles, and translational biochemistry plays a pivotal role in bridging benchside discoveries with clinical application. By elucidating the biochemical underpinnings of disease heterogeneity, translational approaches enable the identification of actionable
The Interface Between Biochemistry and Immunology: Metabolic Regulation of Immune Cell
Smirnov Oleg¹, Tanaka Yuto², Zubair Fariha³, Almeida Sérgio⁴, Fuchs Tobias⁵, Morel Amandine⁶ ABSTRACT: Background: The functional state of immune cells is intricately linked to their metabolic programs, which dynamically adjust in response to environmental cues and immunological demands. The interface between biochemistry and immunology—often termed immunometabolism—has revealed that metabolic pathways are not merely passive providers
The Interface Between Biochemistry and Immunology: Metabolic Regulation of Immune Cell Читать дальше
Biochemical Consequences of Climate Change: Effects on Enzyme Stability and Metabolic Homeostasis in Plants
Volkova Yulia¹, Nakamura Sho², Hassan Amara³, Nogueira Paulo⁴, Weber Simon⁵, Bernard Lucie⁶ ABSTRACT: Background: Climate change imposes multifaceted biochemical stressors on plants, including elevated temperatures, increased atmospheric CO₂, and altered precipitation patterns. These environmental shifts disrupt the finely tuned enzymatic and metabolic networks that underlie plant growth, development, and adaptation. Understanding how climate-induced stress affects
Synthetic Biochemistry for In Vitro Metabolic Engineering: Design, Implementation and Applications
Klimova Ekaterina¹, Takahashi Sora², Jamil Farah³, Ribeiro Vasco⁴, Braun Matthias⁵, Chevallier Maëlle⁶ ABSTRACT: Background: Synthetic biochemistry offers a transformative platform for reconstituting and engineering complex metabolic pathways outside of living cells. By assembling purified enzymes in cell-free systems, this approach decouples metabolic design from cellular growth constraints, enabling unprecedented control over flux distribution, cofactor recycling,