Use of Clinical Pharmacokinetic Models in Oncology Drug Dosing

Chronic kidney disease (CKD) presents a significant challenge in pharmacotherapy due to the altered pharmacokinetics of many medications eliminated primarily through renal pathways. Inadequate dose cleared medications in CKD patients. We discuss current methodologies for estimating renal function—particularly glomerular filtration rate (GFR)—and how these estimates inform individualized drug dosing. Specific drug classes such as antimicrobials, cardiovascular agents, and analgesics are examined with a focus on their renal handling and the impact of declining kidney function on efficacy and safety. Additionally, the importance of interdisciplinary collaboration between pharmacists, nephrologists, and primary care providers is emphasized to optimize patient outcomes. This article aims to provide a practical framework for clinicians to implement safe and effective dosing strategies in the context of impaired renal function.