Clara V. Peterson¹, Michael T. Hughes², Akiko Yamamoto³, Omar S. El-Mahdi⁴, Elena S. Novak⁵, Rahul M. Gupta⁶
ABSTRACT:
Adverse drug reactions (ADRs) represent a significant clinical concern in geriatric patients due to age-related physiological changes, polypharmacy, and the increased vulnerability to side effects. This retrospective analysis examines the incidence, types, and risk factors for ADRs in elderly individuals. Data from medical records were analyzed to identify common drugs associated with ADRs, including antihypertensives, anticoagulants, and central nervous system agents. The study also investigates underlying factors such as comorbidities, renal and hepatic function, and drug interactions that contribute to the heightened risk in this population. Our findings highlight the need for careful medication management, including dose adjustments and regular monitoring, to reduce the incidence of ADRs. Furthermore, we discuss strategies such as deprescribing, the use of therapeutic drug monitoring, and patient education to mitigate risks and improve therapeutic outcomes for geriatric patients.
