Krause Emil¹, Hartmann Sophie², Brandt Theo³, Lorenz Clara⁴, Vogt Julian⁵, Busch Ella⁶,Heinrich Max⁷, Albrecht Mila⁸, Simon Luis⁹
ABSTRACT:
Oxidative stress plays a pivotal role in the pathogenesis of hypertension (HTN) and its cardiac complication, left ventricular hypertrophy (LVH). This review examines the diagnostic and prognostic value of oxidative stress markers, including lipid peroxidation products (MDA, 8-isoprostane), antioxidant enzymes (SOD, GPx), and redox-sensitive signaling molecules (NADPH oxidase activity). We highlight their mechanistic involvement in vascular dysfunction, myocardial remodeling, and transition to heart failure. Clinical applications for early detection, risk stratification, and monitoring of antioxidant therapies are discussed alongside technological advances in redox biomarker quantification. Challenges in standardization and future therapeutic strategies targeting oxidative pathways are critically evaluated.