Müller Paul¹, Schmidt Markus², Wagner Anna³, WeberThomas⁴, Hoffmann David⁵, Bauer Klaus⁶, Becker Victoria⁷
ABSTRACT:
Background: MicroRNAs (miRNAs) have emerged as pivotal regulators of gene expression and are increasingly recognized as promising circulating biomarkers for cancer. Their stability in bodily fluids and tissue-specific expression patterns offer unique advantages for early detection and prognosis.
Methods and Results: This review synthesizes evidence on miRNA signatures across various cancers, their mechanisms of action, and clinical utility in liquid biopsies. We highlight validation studies and technological advances in miRNA detection.
Conclusion: Circulating miRNAs hold transformative potential for cancer management, but challenges in standardization and clinical integration remain.