Kreger Vladimir¹, Khamkhoev Islam², Kuklina Anastasya³, Safronova Olga⁴, Emykova Susanna⁵, Pet'ko Sofia ⁶, Gurin Ivan⁷, Kulyabina Angelina⁸, Chen Haoran9
ABSTRACT:
Hyperlipidaemia, characterized by elevated plasma lipid concentrations, is a significant risk factor for cardiovascular diseases, including atherosclerosis and coronary artery disease. Central to lipid homeostasis are transmembrane cholesterol receptor family proteins, notably the low-density lipoprotein receptor (LDLR) family, which includes LDLR, very-low-density lipoprotein receptor (VLDLR), LDL receptor-related proteins (LRPs), and others. These receptors mediate the endocytosis and clearance of lipoprotein particles, thereby regulating plasma cholesterol levels. This study investigates the expression patterns of key transmembrane cholesterol receptors in hyperlipidaemic conditions using Western blot analysis. We analyzed liver tissue samples from hyperlipidaemic and normolipidaemic subjects to assess the protein expression levels of LDLR, VLDLR, LRP1, and LRP6.