Changes in Presenilin-1 (PS1) Protein Levels in Neurons in Alzheimer’s Disease: Western Blot Analysis Results

Presenilin-1 (PS1) is a crucial component of the γ-secretase complex, which plays a key role in the cleavage of amyloid precursor protein (APP) to generate amyloid-β (Aβ) peptides, implicated in Alzheimer’s disease (AD) pathogenesis. Mutations in the PS1 gene are the most common cause of early-onset familial AD. This study investigates the changes in PS1 protein levels in neurons from post-mortem brain tissue of AD patients, compared to age-matched controls, using Western blot analysis. Our findings show significant alterations in the expression levels of PS1 in neurons affected by AD, suggesting a potential link between PS1 dysregulation and the pathophysiology of the disease. This article provides insights into the role of PS1 in Alzheimer’s disease and its potential as a therapeutic target for intervention.